Kersa HDSS was established in 12 sub-districts of Kersa district, Eastern Hararge, Oromia Region, Ethiopia. The site is principally rural with two small towns (Kersa and Weter). The baseline census was conducted in 2007 and since then has been updated every 6 months, with registration of demographic and health events. Data are entered into the HRS-2 relational database.

It conducts health and demographic surveillance. The major work on the ground are monitoring demographic altering events such as birth, death, and migration; and health related conditions such as pregnancy, immunization, and morbidity. It also conducts verbal autopsy for the deceased to identify causes of death.